The Discovery and Evolution of Liposomes
Liposomes were first described in the 1960s by British haematologist Alec D. Bangham, who discovered them while studying cell membranes. These tiny, spherical vesicles are composed of phospholipid bilayers, which closely resemble the structure of cell membranes. This similarity allows liposomes to encapsulate both hydrophilic (water-soluble) and hydrophobic (fat-soluble) substances, making them highly versatile for drug delivery.
In medicine, liposomes were initially explored as a vehicle for delivering drugs, particularly chemotherapy agents. Their ability to encapsulate drugs meant that they could deliver treatments directly to target tissues, minimising side effects and enhancing efficacy. Over the decades, liposome technology advanced, leading to the development of liposomal formulations for various therapeutic agents, including antibiotics, antifungals, and vaccines.
Introduction of Liposomes to Vitamin C
The concept of using liposomes to deliver nutrients, including Vitamin C, gained traction in the early 2000s. Vitamin C, also known as ascorbic acid, is a potent antioxidant with numerous health benefits. However, its bioavailability when taken orally is limited because the body regulates its absorption through the intestines, and excess amounts are rapidly excreted through urine.
Liposomal Vitamin C offers a solution to this problem by encapsulating the ascorbic acid in liposomes. This encapsulation protects Vitamin C from being degraded by the digestive system and allows it to be absorbed directly into the bloodstream. The liposomal delivery system enhances the bioavailability of Vitamin C, ensuring that higher concentrations reach the cells where it is needed.
Benefits of Liposomal Vitamin C
1. Increased Bioavailability: Traditional oral Vitamin C has a bioavailability limit, with only a fraction of the dose reaching the bloodstream. Liposomal Vitamin C, however, bypasses the body's regulatory absorption mechanisms, leading to much higher bioavailability.
2. Sustained Release: Liposomes can provide a sustained release of Vitamin C into the bloodstream, maintaining higher levels for a longer period. This continuous supply is particularly beneficial for supporting immune function and reducing oxidative stress.
3. Enhanced Cellular Uptake: The phospholipid bilayer of liposomes facilitates the fusion with cell membranes, promoting the direct delivery of Vitamin C into the cells. This targeted approach improves the effectiveness of Vitamin C at the cellular level.
4. Reduced Gastrointestinal Discomfort: High doses of traditional Vitamin C can cause gastrointestinal issues, such as diarrhoea and cramps. Liposomal Vitamin C is gentler on the digestive system, reducing the likelihood of these side effects.
5. Potential for Higher Doses: Because of its improved bioavailability and reduced gastrointestinal side effects, liposomal Vitamin C allows for higher dosing, which can be particularly beneficial in therapeutic contexts, such as combating severe infections or supporting recovery from illness.
Conclusion
The integration of liposome technology into Vitamin C supplementation represents a significant advancement in nutritional science. By enhancing the bioavailability and effectiveness of Vitamin C, liposomal formulations provide a powerful tool for supporting health, particularly in immune support, skin health, and overall antioxidant protection. As research continues, the potential applications of liposomes in delivering other nutrients and pharmaceuticals will likely expand, offering new avenues for improving health and wellness.
Radiant-C Liposomal Vitamin C utilises the phospholipids found naturally in sunflower lecithin to create liposomes to encapsulate the vitamin C. It has been independently tested and verified to contain liposomes in the 80-100 nanometer range; the perfect size for passing through cell membranes.
